Continuous-flow synthesis of β-amino alcohols
Assignee: Helios Pharma. Co-inventors: Whitfield, E. M.; Acharya, R.
ProcessContinuous flowA representative sample. Full reference list available under NDA upon request.
PhD, Synthetic Organic Chemistry — ETH Zürich, 2008
Dissertation: “Asymmetric Catalysis with Chiral N-Heterocyclic Carbene–Iridium Complexes for β-Amino Alcohol Synthesis.”
Advisor: Prof. K. Mannheim · ETH Medal for Doctoral Thesis.
2008–2017
MIT — Postdoctoral Fellow with Prof. R. Tanaka (2 yrs). Then Senior Research Scientist at Helios Pharma, leading the API process group for two NDA programs.
Assignee: Helios Pharma. Co-inventors: Whitfield, E. M.; Acharya, R.
ProcessContinuous flowAssignee: Helios Pharma. Co-inventors: Whitfield, E. M.; Park, J.; O'Donnell, S.
FormulationSolubilityAssignee: ETH Zürich. Co-inventors: Whitfield, E. M.; Mannheim, K.
CatalysisAssignee: Atlas Polymers. Co-inventors: Whitfield, E. M.; Lindqvist, A.
MaterialsCoatings+ 10 additional granted patents and 6 pending applications.
Identified a genotoxic impurity pathway and redesigned the penultimate step, reducing impurity below ICH M7 thresholds and saving an estimated 14 months of regulatory rework.
Co-developed a waterborne coating system that met California SCAQMD limits while matching salt-spray performance of the legacy solvent-based formulation.
Authored two expert reports and gave deposition testimony on the obviousness of a continuous-flow process; matter resolved favorably for the client at summary judgment.
“Continuous Manufacturing in Late-stage API Development,” Lisbon, PT.
“Mechanistic insights into Pd-catalyzed C–N coupling at flow regime.” Whitfield, E. M.; Park, J.
“Amorphous solid dispersions of poorly soluble kinase inhibitors.” Whitfield, E. M., et al.
“Chiral NHC–Ir complexes for asymmetric reduction.” Mannheim, K.; Whitfield, E. M.
“From bench to kilo-lab: avoiding the top five scale-up traps.”